We aim in this paper to address the sustainability challenge of how an integrated approach can lead to figuring out solutions to complex issues for modern societies. We reviewed papers related to integrated water resource management (IWRM) and integrated solid waste management (ISWM) to advocate some innovative concepts and methodologies of sustainability science. An investigation of the concepts of IWRM and ISWM over various sustainability science research clusters and dimensions is presented. Water resource management projects at different scales and across various geographical boundaries are reviewed to understand the IWRM approach. The ISWM approach is discussed with regard to research topics and methodologies from selected case studies in developed and developing countries. We sought to look at various definitions, the integrated elements, and the similarities and differences between the two approaches. We also present our definitions for each approach. Our findings show how integrated thinking can help in achieving sustainable development. Finally, we present our recommendations for possible implications to the integrated approach in order to accelerate the process of sustainable development.